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Stem Cell Research Scientist

Vertex Pharmaceuticals · Boston, MA

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ResearchFull-time$104k–$156kCompany career page

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Role summary

Vertex Pharmaceuticals seeks a Stem Cell Research Scientist in Boston to advance cell-based therapies for type 1 diabetes. The role involves designing and executing stem cell differentiation experiments, developing functional assays, and collaborating across research teams to support discovery and preclinical development programs.

What they're looking for

  • Hands-on expertise with pluripotent stem cell culture, maintenance, expansion, and directed differentiation protocols
  • Experience designing and executing complex in vitro and ex vivo experiments with primary islets and stem cell-derived models
  • Proficiency with cell-based functional assays and molecular biology techniques (flow cytometry, Western blotting, immunohistochemistry, scRNA-seq)
  • Knowledge of developmental biology and familiarity with omics-based approaches including transcriptomics and single-cell analysis
  • Strong scientific communication skills with demonstrated productivity evidenced by publications
  • Prior experience in biotech or pharmaceutical drug discovery/translational research preferred; mentoring experience preferred

What you'll be doing

  • Design, execute, and analyze complex in vitro and ex vivo experiments using primary islets and stem cell-derived islet models
  • Develop and optimize cellular assays for phenotypic and physiological characterization of islet biology
  • Execute stem cell differentiation campaigns including pluripotent stem cell maintenance, expansion, and directed differentiation
  • Apply molecular and cellular techniques to characterize stem cell models and interpret complex biological datasets
  • Collaborate with cross-functional teams on translational and preclinical research objectives; maintain detailed experimental records and scientific documentation

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