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Principal Scientist, Pharmacokinetics, Biologics

Merck · Boston (MA Parcel B Laboratory), MA

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ResearchFull-time$176k–$277kCompany career page

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Role summary

Principal Scientist position leading bioanalytical strategies for biologics in drug discovery. The role involves managing a team of scientists, developing ligand binding assays and mass spectrometry methods, and collaborating across immunology and oncology programs at the Boston research facility.

What they're looking for

  • Ph.D. in biochemistry, chemistry, pharmacology, or related field with 6+ years relevant experience
  • Demonstrated leadership of bioanalytical strategies for biologics including method development and data interpretation
  • Experience analyzing pharmacokinetic, pharmacodynamic, and immunogenicity data for protein therapeutics
  • Proven management experience mentoring multiple direct reports
  • Strong communication, problem-solving, and cross-functional collaboration skills
  • Technical expertise in ligand binding assays and mass spectrometry bioanalytical approaches

What you'll be doing

  • Lead bioanalytical strategies for drug discovery portfolio focused on biologics and modalities
  • Manage team of laboratory scientists developing and executing ligand binding and mass spectrometry assays
  • Serve as subject matter expert and project-team representative for DMPK activities in oncology and immunology
  • Contribute to global DMPK strategy through collaboration with Discovery and Early Development teams across multiple sites

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