Principal Scientist, Biologics Optimization
Johnson & Johnson · Spring House, PA
ResearchFull-timeCompany career page
The apply link worked recently (not employer-confirmed).
Role summary
Principal Scientist role leading biologics optimization within Johnson & Johnson's Innovative Medicine division. The position focuses on designing and optimizing biologic variants across therapeutic modalities using protein engineering, computational, and AI/ML approaches to achieve differentiated functional outcomes.
What they're looking for
- Master's degree in molecular biology, biochemistry, biotechnology, or related field (PhD strongly preferred)
- Minimum 3 years industry experience in biologics discovery, protein engineering, or therapeutic optimization
- Demonstrated scientific leadership and expertise in biologics optimization for functional outcomes
- Deep understanding of antibody structure-function relationships and CDR design strategies
- Proficiency with display technologies, structure-guided design, and computational approaches
- Strong project management and independent scientific decision-making capabilities
What you'll be doing
- Lead biologics optimization across multiple therapeutic programs, translating target biology into protein engineering strategies
- Develop and implement optimization strategies integrating sequence, structure, developability, and biological function
- Partner with therapeutic area and computational teams to define functional hypotheses and screening cascades
- Apply AI/ML and data-driven approaches to guide variant design and library construction decisions
- Present scientific findings independently and manage project timelines across multi-functional teams
Privacy & handoff
This role links to Johnson & Johnson's own application system. RoleLantern records your interest and checks the link, but the application happens on the employer's site and status updates may not come back to us. Clicking apply does not mark you as applied automatically.