Optics / Microscopy Principal Scientist
Vertex Pharmaceuticals · San Diego, CA
ResearchFull-time$144k–$217kCompany career page
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Role summary
Vertex Pharmaceuticals seeks a Principal Scientist to design and develop custom optical instruments for drug discovery. The role combines expertise in optical design, microscopy, and functional imaging with cross-disciplinary collaboration in a fast-paced applied physics and engineering environment.
What they're looking for
- Ph.D. in Physics, Physical Chemistry, Bioengineering, or related discipline
- 8+ years hands-on experience developing novel imaging platforms or optical technologies
- Deep knowledge of optical design principles including ray tracing and optical aberrations
- Proficiency in programming for data analysis and instrument control
- Experience with functional cell measurements such as voltage or calcium imaging
- Expertise in multiple biological imaging modalities like fluorescence or confocal microscopy
- Experience supervising and mentoring junior researchers or staff
What you'll be doing
- Collaborate with cross-disciplinary teams to identify where custom instrumentation can advance projects
- Design and build prototype optical instruments and conduct proof-of-concept experiments
- Work with engineers to specify, design, and develop production-ready automated instruments
- Optimize assays in partnership with biologists and chemists
- Communicate findings through written reports, presentations, and stakeholder discussions
Privacy & handoff
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