Discovery Immunology Principal Research Scientist

Vertex Pharmaceuticals · Seattle, WA

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ResearchFull-time$140k–$210kCompany career page

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Role summary

Vertex Pharmaceuticals seeks a Discovery Immunology Principal Research Scientist to lead immunology programs targeting autoimmune diseases. The role encompasses target identification, disease mechanism investigation, and early drug discovery, requiring deep expertise in immunology, translational science, and collaborative leadership in a laboratory-based setting.

What they're looking for

PhD in immunology, cell biology, molecular biology, or related life science; or bachelor's degree with 10+ years hands-on laboratory experience
Substantial industry or postdoctoral discovery research experience with scientific leadership of early-stage programs
Deep expertise in autoimmune, inflammatory, and immune-mediated disease biology
Proficiency in immunology assays, flow cytometry, cell-based testing, and mechanistic studies
Strong publication record and demonstrated scientific contributions
Experience mentoring scientists or leading research teams in matrixed environments
Familiarity with single-cell, genomic, proteomic, or systems-immunology approaches preferred

What you'll be doing

Lead immunology discovery programs from target identification through mechanism-of-action studies and strategy development
Design, oversee, and interpret in vitro, ex vivo, and in vivo studies across innate and adaptive immunity
Develop disease-relevant models and innovative experimental approaches aligned with translational strategies
Collaborate across chemistry, computational biology, and project management to advance programs and communicate findings
Mentor scientists and contribute to publications, presentations, and competitive landscape tracking

Key requirements

Therapeutic area: Immunology

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