Computational Chemistry Principal Research Scientist (Computational Drug Design)
Vertex Pharmaceuticals · Boston, MA
ResearchFull-time$145k–$217kCompany career page
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Role summary
Vertex Pharmaceuticals seeks a computational chemist to lead drug design initiatives using molecular modeling, cheminformatics, and AI methods. The role involves advancing hit/lead identification programs, mentoring junior scientists, and collaborating across discovery teams in Boston on a hybrid basis.
What they're looking for
- Ph.D. in Computational Chemistry or equivalent with 6+ years drug design experience
- Expertise in structure-based design and small-molecule optimization
- Proficiency with commercial and open-source molecular modeling software
- Programming skills in Python and data analysis capabilities
- Experience applying modern AI computational methods to drug discovery
- Strong interpersonal, communication, and presentation abilities
What you'll be doing
- Apply computational chemistry methods to accelerate drug candidate discovery and design
- Provide scientific leadership across discovery programs and guide computational approaches
- Partner with medicinal chemists to generate design hypotheses and drive experimental decisions
- Evaluate and advance AI-enabled approaches for molecular design and prediction
- Mentor junior scientists and establish computational best practices
Privacy & handoff
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