Senior Scientist I, Cell Therapy Discovery
AstraZeneca · Guilin Road
ResearchFull-timeCompany career page
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Role summary
Senior Scientist I role focused on CAR-T cell engineering and discovery at AstraZeneca's Shanghai site. Responsibilities include leading CAR construct design, developing in vitro functional assays, and driving cross-functional collaboration to advance cell therapy programs toward translation.
What they're looking for
- PhD in immunology, cell biology, or related discipline; or MS with 2–3+ years cell therapy discovery impact
- Human T-cell isolation, activation, and culture expertise
- Lentiviral transduction and electroporation for gene editing
- Flow cytometry panel design, gating, and advanced phenotyping
- Functional assay development including target killing and persistence studies
- Molecular methods: PCR/qPCR, plasmid prep, amplicon NGS
- Proficiency with ELN, FlowJo, GraphPad; BSL-2 and GxP compliance awareness
What you'll be doing
- Lead CAR construct design and optimize in vitro functional characterization assays
- Characterize engineered cell therapies using human primary cells and co-culture systems
- Apply data-driven approaches to experimental design and mechanism-of-action studies
- Drive cross-functional alignment with pharmacology, CMC, and clinical teams
- Present results and mentor colleagues to support program milestones
Privacy & handoff
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