Principal Scientist, Upstream Process Development Group Lead
Merck · Rahway, NJ
CMCFull-time$173k–$273kCompany career page
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Role summary
Merck seeks a Principal Scientist to lead upstream bioprocess development for biologics in the Biologics Process Research & Development group. The role involves driving strategic initiatives, designing scalable cell-culture processes, and directing a team of 3-5 scientists while collaborating across functions to advance drug candidates through development and commercialization.
What they're looking for
- Ph.D. with 10+ years or MS with 12+ years industry experience in chemical/biochemical engineering or related field
- Deep expertise in cell-culture process development, fed-batch systems, and bioreactor scale-up
- Track record of peer-reviewed publications and presentations in upstream bioprocessing
- Knowledge of biologics CMC development and regulatory pathways
- Demonstrated scientific leadership with measurable impact across multiple programs
- Experience supervising and mentoring cross-functional teams in matrixed environments
- Strong problem-solving and prioritization skills in fast-paced, complex settings
What you'll be doing
- Lead upstream process development strategy and drive innovation across biologics pipeline
- Design, execute, and direct cell-culture process development from early to late-stage programs
- Develop robust, scalable bioprocesses and prepare process characterization for regulatory submissions
- Supervise 3-5 scientists, guide their professional development, and mentor expertise sharing across teams
- Evaluate emerging technologies and industry best practices to improve process efficiency and cost-effectiveness
Privacy & handoff
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