Principal Scientist

Regeneron · Tempel LN

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ResearchFull-time$108k–$176kCompany career page

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Role summary

Regeneron is hiring a Principal Analytical Scientist to develop and validate analytical methods for oligonucleotide and peptide therapeutics in a manufacturing and quality control setting. The role involves method development, technology implementation, troubleshooting, and cross-functional collaboration to support GMP operations. Candidates need a PhD in Chemistry or related field plus 3+ years of analytical chemistry experience.

What they're looking for

PhD in Chemistry, Biochemistry, Biology, or related field
3+ years industry experience in analytical development and QC method lifecycle
Proficiency with LC-MS/MS, CE, ion-pair RP-HPLC, and peptide mapping techniques
Demonstrated experience with iSRNA/siRNA oligonucleotide and peptide therapeutic methods
Strong technical writing, data integrity practices, and presentation skills
Proven method transfer, troubleshooting, and OOS/OOT investigation experience

What you'll be doing

Develop, optimize, and validate analytical methods for iSRNA/siRNA and peptide modalities
Design and review assay qualification and validation protocols following ICH Q2 principles
Identify, assess, and implement new instrumentation and analytical technologies
Transfer control test procedures to QC with transfer plans, training, and acceptance criteria
Lead troubleshooting, OOS/OOT investigations, and deviation root-cause analysis support

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Date posted43 days ago

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