Principal Scientist--Pharmacokinetics, Dynamics and Metabolism

Pfizer · Groton, CT

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ResearchFull-time$106k–$177kCompany career page

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Role summary

Principal Scientist position within ADME Sciences focused on pharmacokinetics and metabolism. The role involves leading quantitative metabolism workstreams for small molecule drug discovery and development, managing ADME strategy, risk assessment, and providing scientific recommendations to project teams.

What they're looking for

PhD in related science with 4+ years ADME industry experience, or MS with 9+ years, or BS with 12+ years
Knowledge of enzymology, drug metabolism, enzyme kinetics, reaction phenotyping, and DDI principles
Independent experience leading complex ADME workstreams with study design and data interpretation
Strong written and verbal communication for technical reports and presentations
Experience mentoring and coaching scientists through experimental planning and data review

What you'll be doing

Serve as ADME scientific owner for assigned project questions and influence strategy on discovery and development teams
Design, execute, and interpret enzymology studies addressing clearance, disposition, and drug-drug interaction risk
Integrate in vitro ADME data to identify liabilities and propose mitigation strategies
Lead risk assessments for clearance mechanisms, enzyme involvement, and induction or inhibition liabilities
Mentor scientists through experimental oversight, technical guidance, and coaching to build scientific independence

Key requirements

Therapeutic area: Metabolic

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