Principal Scientist, Protein Engineering

Xaira Therapeutics · South San Francisco, CA

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Role summary

Xaira Therapeutics seeks a Principal Scientist to lead protein engineering efforts in AI-driven therapeutic discovery. The role combines hands-on experimental work with scientific leadership, partnering with computational designers to develop protein and antibody therapeutics against challenging targets.

What they're looking for

Ph.D. in molecular biology, biochemistry, or related field
Deep expertise in protein engineering and antibody format development
Strong knowledge of developability metrics and biophysical characterization
Demonstrated ability to lead scientific strategy and mentor junior scientists
Experience designing and executing protein optimization campaigns
Proficiency with chromatographic and biophysical assay techniques

What you'll be doing

Define scientific strategy for therapeutic programs and develop AI-driven discovery strategies
Guide computational protein design campaigns and interpret structural insights for optimization
Lead binder discovery and screening campaigns, prioritizing strategies and identifying hits
Design, produce, and characterize therapeutic proteins and antibodies using laboratory techniques
Mentor junior staff and oversee cross-functional program communication and CRO management

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