Principal Scientist, Biologics Optimization

Johnson & Johnson · Spring House, PA

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Role summary

Principal Scientist position in biologics optimization at Johnson & Johnson's Spring House, PA facility. Leads integration of experimental data, engineering insights, and automation technologies to advance biologic drug discovery and establish design principles for molecule optimization.

What they're looking for

Master's degree in molecular biology, biochemistry, biotechnology, biomedical engineering, or structural biology
Expertise in biologics discovery, antibody engineering, and optimization platforms
Experience with yeast display, NGS, high-throughput screening, or related discovery technologies
Demonstrated proficiency in data-driven research and analytical approaches
Strong background in laboratory automation integration and workflow optimization
Leadership experience collaborating across cross-functional scientific teams

What you'll be doing

Lead scientific strategy for automation-enabled workflows in yeast display, NGS, and biologics optimization platforms
Partner with automation and therapeutic area teams to implement and improve discovery technologies across sites
Develop data-driven approaches to establish sequence-structure-function relationships and design principles
Collaborate with computational and AI/ML scientists to enhance biological understanding and discovery efficiency
Evaluate emerging technologies and present scientific findings to support portfolio-wide optimization decisions

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