Senior Scientist - Experimental Protein Design for Target Discovery
Amgen · South San Francisco, CA
ResearchFull-timeCompany career page
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Role summary
Amgen seeks a Senior Scientist to develop high-throughput platforms for experimental protein binder generation and validation. The role integrates computational designs with rapid experimental testing to advance target discovery and early-stage therapeutic development across diverse disease areas.
What they're looking for
- PhD in Biochemistry, Protein Engineering, Bioengineering, or Structural Biology with postdoctoral experience
- Demonstrated expertise in protein expression, purification, and biochemical characterization of engineered proteins
- Experience with binder validation using flow cytometry, SPR, and cellular assays
- Knowledge of protein structure-function relationships and designed binder engineering
- Ability to translate computational designs into experimentally testable reagents
- Experience with automation and high-throughput experimentation platforms
- Strong cross-functional collaboration and communication skills
What you'll be doing
- Translate computational protein designs into validated minibinders and antibodies across multiple targets
- Lead high-throughput workflows for binder expression, purification, and characterization
- Develop and optimize cellular assays for binder-target evaluation and functional screening
- Partner with molecular biology teams to establish construct generation and library production workflows
- Analyze experimental data to guide iterative design-build-test cycles and advance discovery strategies
Privacy & handoff
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