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Senior Scientist, Cell Pharmacology

Xilio Therapeutics · Waltham, MA

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Role summary

Xilio Therapeutics seeks a Senior Scientist in Cell Pharmacology to develop and execute cell-based assays supporting immuno-oncology drug discovery. The role involves designing functional assays, implementing automation, and generating data to advance the company's tumor-activated therapeutic pipeline.

What they're looking for

  • BS/MS/PhD in Biology or related field with 7+ years (BS), 5+ years (MS), or 3+ years (PhD) post-graduate experience
  • Strong background in immunology, IO, or T-cell engager development
  • Proficiency with flow cytometry, ELISA, and MSD-based assays
  • Expertise in primary human cell culture and cell-based assay development
  • Experience with liquid handling automation and robotics for high-throughput screening
  • Technical skills in western blots and protease characterization assays

What you'll be doing

  • Develop and execute functional cell-based and cell-free in vitro assays for drug discovery programs
  • Design and implement automation strategies using liquid handling robotics to increase assay throughput
  • Conduct phenotypic assays, reporter gene assays, binding assays, and enzymatic cleavage experiments
  • Culture primary human tumor and immune cells for ex vivo experimental work
  • Mentor junior scientists and represent cell pharmacology function at project team meetings
Compensation$126,000-$147,500

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