Senior RNA Chemist – RNA Therapeutics

Amgen · Thousand Oaks, CA

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Role summary

Amgen seeks a Senior RNA Chemist to advance mRNA therapeutic platform technologies in Thousand Oaks, California. The role focuses on mRNA design, synthesis, purification, and characterization to enable next-generation medicine discovery. The chemist will lead experimental efforts, develop platform technologies including chemical modifications and sequence optimization, and collaborate with cross-functional teams to improve RNA stability and manufacturability.

What they're looking for

PhD in chemistry, biochemistry, or related field; or PharmD/MD with postdoc; or Master's with 3+ years relevant experience; or Bachelor's with 5+ years relevant experience
Expertise in RNA chemistry, oligonucleotide chemistry, or nucleic acid therapeutics
Hands-on experience with in vitro transcription, RNA purification, and analytical characterization
Proficiency with analytical methods including HPLC, FPLC, LC-MS, gel electrophoresis, and capillary electrophoresis
Knowledge of modified nucleotides, capping technologies, and RNA structure-function relationships
Experience designing and executing experiments independently with strong troubleshooting abilities
Demonstrated scientific communication through publications, patents, or technology advancement

What you'll be doing

Design and implement high-throughput strategies for modular mRNA assembly with therapeutic applications
Develop mRNA platform technologies including chemical modifications, capping, and sequence optimization
Lead efforts to improve RNA quality, purity, stability, and biological activity through experimentation
Develop and apply purification strategies for mRNA using FPLC and related chromatography methods
Utilize analytical characterization techniques to evaluate impact of modifications on mRNA performance and developability

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Date posted30 days ago

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