Senior Research Scientist

ICON · Wilmington, DE +1 more

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Role summary

ICON seeks a Senior Research Scientist to design and optimize recombinant protein constructs, manage expression in bacterial, insect, and mammalian systems, and develop purification workflows for proteins and antibodies. The role involves characterization, quality control, and support of drug discovery and structural biology programs.

What they're looking for

PhD in Biochemistry, Biophysics, Protein Chemistry, Molecular Biology, or related field with 2+ years relevant experience, or Master's degree with 5+ years in drug discovery/biotech
Hands-on expertise in recombinant protein expression, purification, and biophysical characterization
Experience purifying and characterizing antibodies and antibody fragments with workflow optimization
Proficiency with affinity, ion-exchange, and size-exclusion chromatography techniques
Experience with SEC-HPLC, DSF/thermal stability assays, BLI, SPR, and related analytical methods
Demonstrated ability to troubleshoot protein expression and purification challenges independently
Proven project management skills with ability to handle multiple concurrent priorities

What you'll be doing

Design and optimize recombinant protein constructs for expression in bacterial, insect, and mammalian cell systems
Develop and execute protein and antibody purification workflows using chromatography and related techniques
Characterize purified proteins and antibodies using biochemical and biophysical analytical methods
Establish quality-control criteria and assess purity, aggregation, stability, and batch consistency
Generate high-quality protein samples for crystallography, cryo-EM, and structural biology applications

CompensationCompetitive base salary and performance-related incentives

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Date posted16 days ago

Last source check1 day ago

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