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Senior Principal Scientist

Pfizer · Pearl River, NY

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ResearchFull-time$124k–$207kCompany career page

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Role summary

Senior Principal Scientist position within Pfizer's Vaccines R&D group focused on analytical strategy and method development for early-phase vaccine candidates. The role combines scientific leadership of a research team with hands-on expertise in analytical characterization of complex biologics, requiring extensive experience in method development, qualification, and cross-functional collaboration.

What they're looking for

  • PhD in analytical chemistry, biochemistry, pharmaceutical sciences, or related discipline with 8+ years experience
  • Advanced expertise in analytical method development and characterization of biologics or vaccine modalities
  • Demonstrated scientific team leadership including prioritization, guidance, coaching, and talent development
  • Extensive hands-on experience with separation techniques such as liquid chromatography or capillary electrophoresis
  • Proven track record of method development, qualification, transfer, and technical documentation across programs
  • Ability to influence cross-functional teams, communicate complex conclusions to diverse audiences, and manage data integrity

What you'll be doing

  • Define and lead analytical control strategies for multiple vaccine programs aligned with product quality and development milestones
  • Manage and provide scientific direction to a team of scientists with focus on execution and professional development
  • Lead development, optimization, qualification, and lifecycle management of separation-based and physicochemical analytical methods
  • Represent analytical development on cross-functional teams; communicate technical risks and data-driven recommendations to leadership
  • Drive innovation in analytical technologies, automation, and digital tools to enhance scientific insight and decision quality

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