Senior Computational Scientist

Twist Bioscience · South San Francisco, CA

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Role summary

Twist Bioscience seeks a Senior Computational Scientist to develop AI and machine learning solutions for protein design and discovery. The role combines computational biology, algorithm development, and collaboration with experimental teams to create tools for sequence design, evaluation, and candidate selection.

What they're looking for

PhD in computational biology, bioinformatics, machine learning, computer science, or protein science
Minimum 5 years industry experience post-PhD
Extensive algorithm development experience in protein design, engineering, discovery, or sequence analysis
Demonstrated proficiency with AI/ML methods applied to proteins or biological sequences
Strong understanding of protein language models and sequence-structure-function relationships
Python programming expertise and hands-on experience with PyTorch or TensorFlow
Experience analyzing NGS data from biological selection or screening workflows

What you'll be doing

Develop algorithms integrating protein sequences with NGS and experimental data to inform design cycles
Design and apply AI/ML methods for therapeutic protein sequence optimization and evaluation
Lead computational analyses for protein discovery programs including sequence selection and clone prioritization
Translate scientific needs into practical computational solutions with software and bioinformatics teams
Collaborate across experimental, engineering, and customer-facing teams on discovery programs

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Date posted16 days ago

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