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Principal Scientist (Director), Translational Medicine - Cardiovascular

Merck · Boston (MA Parcel B Laboratory), MA +4 more

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ResearchFull-time$260k–$410kCompany career page

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Role summary

Leadership position in translational medicine focused on cardiovascular therapeutic development. Responsible for early clinical strategy from preclinical approval through Phase 2 proof-of-concept, including biomarker development and clinical pharmacology studies in collaboration with discovery and clinical research teams.

What they're looking for

  • MD or MD/PhD degree
  • Proven track record in clinical medicine or clinical research with biomedical research background
  • Demonstrated scientific achievement through publications or presentations
  • Strong interpersonal, writing, and presentation skills
  • Board certification or eligibility in clinical specialty preferred
  • Prior translational research or early clinical development experience preferred
  • Expertise in cardiovascular medicine or related subspecialties preferred

What you'll be doing

  • Lead early clinical development strategy design and execution for novel cardiovascular therapy programs
  • Develop and execute biomarker strategies and experimental medicine studies from first-in-human through proof-of-concept phases
  • Design clinical pharmacology studies and strategies supporting development phases one through four
  • Provide clinical expertise for target identification and validation through preclinical and clinical experiments
  • Coordinate Phase 1 study execution and communicate results to governance committees and functional experts

Key requirements

Therapeutic area
Cardiovascular

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