Principal Manufacturing Systems Engineer

Amgen · Thousand Oaks, CA +3 more

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IT & SoftwareFull-timeCompany career page

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Role summary

Amgen seeks a Principal Manufacturing Systems Engineer to lead large-scale operations technology projects across global manufacturing sites. The role combines program management, systems engineering, and team leadership to drive productivity through process optimization and automation in GMP-regulated environments.

What they're looking for

Bachelor's degree and 6 years of information systems or manufacturing process automation experience
Expertise in operations technology platforms such as Aveva Pi, DeltaV, Rockwell, or MES systems
Strong program and project management skills with Agile methodology proficiency
Knowledge of GAMP lifecycle, ANSI/ISA standards (S88, S95), and 21 CFR Part 11 compliance
Leadership experience managing cross-functional teams in GMP manufacturing environments
Financial management and vendor performance oversight capabilities

What you'll be doing

Lead large capital projects and product teams using Agile delivery within GMP manufacturing environments
Partner with site and global stakeholders to prioritize demand, manage backlogs, and align local and global strategy
Establish global standards, templates, and best practices for operations technology project design and deployment
Ensure solutions meet GMP compliance, data integrity, and regulatory inspection readiness requirements
Own the global operations technology roadmap including upgrades, standardization, and site deployments

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