Immunology Senior Research Scientist - Spatial Transcriptomics

Vertex Pharmaceuticals · Seattle, WA

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ResearchFull-time$124k–$186kCompany career page

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Role summary

Vertex Pharmaceuticals seeks a Senior Research Scientist with deep expertise in spatial transcriptomics to lead mechanistic studies in immunology and related disease areas. The role involves designing and executing spatial profiling studies, integrating multi-modal datasets, and collaborating across discovery and development teams to generate biological insights.

What they're looking for

Deep expertise in spatial transcriptomics and tissue-based molecular profiling
PhD in immunology, cell biology, molecular biology, or related field with 2+ years experience; or Master's with 6+ years; or Bachelor's with 8+ years
Strong understanding of transcriptomics, RNA biology, and cellular heterogeneity
Experience with fresh frozen and FFPE tissue processing and assay optimization
Proficiency in R and/or Python with working knowledge of computational spatial analysis tools
Hands-on experience with spatial transcriptomics platforms such as 10x Visium or Nanostring CosMx
Ability to integrate spatial data with single-cell RNA-seq, proteomics, and imaging datasets

What you'll be doing

Lead design, execution, and optimization of spatial transcriptomics studies addressing key biological questions in disease-relevant tissues
Characterize tissue architecture, cellular microenvironments, and spatial organization of biological processes
Generate and interpret spatial data to derive insights supporting disease biology, target biology, and biomarker strategies
Develop and validate robust workflows for sample preparation, assay execution, quality control, and data review
Partner with cross-functional teams to inform study design, data interpretation, and program strategy across discovery and development

Key requirements

Therapeutic area: Immunology

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