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Associate Scientist, Post Doc Fellow- AI/ML & Computational Biology for Antigen Design

Merck · West Point, PA

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ResearchFull-time$82k–$92kCompany career page

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Role summary

Postdoctoral scientist position in computational vaccine discovery at Merck, focused on developing AI/ML and structural biology approaches to design stabilized viral antigens. The role combines algorithm development, molecular dynamics integration, and iterative experimental validation within an academic-style research environment.

What they're looking for

  • PhD in computational biology, bioinformatics, computer science, biophysics, or related quantitative field (or expected by spring 2027)
  • Demonstrated experience developing or applying machine learning models to biomolecular data
  • Strong proficiency in Python and modern ML frameworks such as PyTorch or JAX
  • First-author peer-reviewed publications, preprints, or major conference presentations
  • Practical fluency with protein language models, folding models, or structural inverse-folding paradigms
  • Experience with high-performance computing, GPU workflows, version control, and reproducible software development

What you'll be doing

  • Develop, benchmark, and deploy novel AI/ML architectures for protein variant prediction and conformational stabilization
  • Integrate molecular dynamics simulations and energetic modeling with deep learning representations to model dynamic protein transitions
  • Interface with high-throughput experimental screening platforms to iteratively refine and retrain candidate models using empirical data
  • Author manuscripts and present findings at computational biology and vaccine development conferences
  • Collaborate across structural biology, virology, immunology, and computing teams to translate computational advances into vaccine designs

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