Associate Principal Scientist, Upstream Development

Merck · Rahway, NJ

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CMCFull-time$142k–$224kCompany career page

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Role summary

Merck's Biologics Process Research & Development organization seeks an Associate Principal Scientist to lead upstream cell culture process development for biotherapeutics. The role involves designing scalable manufacturing processes, supporting regulatory filings, and advancing platform technologies through cross-functional collaboration and innovation.

What they're looking for

Ph.D. with 4+ years experience, or Master's with 8+ years, or Bachelor's with 12+ years in chemical/bioengineering
Hands-on experience with mammalian cell culture, fed-batch processes, and recombinant protein production
Deep knowledge of CHO cell biology, metabolism, and large-scale bioreactor engineering principles
Proficiency with statistical methods, design of experiments, and analysis software such as JMP or SIMCA
Proven track record of upstream process development with strong publication and presentation record
Strong cross-functional collaboration skills and ability to work in matrixed team environments

What you'll be doing

Lead or participate in upstream process development for first-in-human and commercial cell culture processes
Execute process development, characterization, and regulatory documentation to support PPQs and BLAs
Partner across discovery, analytics, and manufacturing to develop integrated process solutions with quality by design
Drive process improvement initiatives to increase efficiency and reduce manufacturing costs
Collaborate with external partners and vendors on adoption of new process technologies and maintain scientific presence through publications and patents

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