Associate Director, Translational PK/PD

Merck · South San Francisco (grand Ave), CA +2 more

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ResearchFull-time$157k–$247kCompany career page

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Role summary

The Translational PK/PD Associate Director leads mathematical modeling efforts for drug discovery, designing and executing analyses to inform decisions on biologics, protein therapeutics, and peptides across therapeutic areas. The role requires expert-level pharmacokinetic/pharmacodynamic modeling with minimal supervision and involves cross-functional collaboration to guide translational strategy.

What they're looking for

Master's degree with 8+ years, PharmD with 6+ years, or Ph.D. with 4+ years in pharmacokinetics/pharmacodynamics or related discipline
Hands-on translational PK/PD modeling experience using standard software (Matlab, OSP Suite, Monolix, R)
Expert skills in experimental design, mathematical problem solving, data analysis, and statistics
Demonstrated experience with biologics, protein therapeutics, or peptides in discovery/development settings
Demonstrated experience working in interdisciplinary teams and collaborative problem planning
Expertise developing novel modeling strategies or automated workflows using PBPK or QSP approaches

What you'll be doing

Serve as expert PK/PD modeler in cross-functional teams, making model-informed decisions on drug selection and dose prediction
Integrate in vitro and in vivo data to build mechanistic modeling platforms supporting translational strategy
Design experimental studies and modeling plans collaboratively to optimize drug candidates across programs
Guide design of automated workflows implementing modeling platforms for human PK/PD projections
Provide scientific and modeling guidance to junior colleagues and demonstrate leadership in partnerships

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