Senior Scientist – Quantitative LC-MS Protein Bioanalysis

Amgen · South San Francisco, CA

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Role summary

Amgen seeks a Senior Scientist to develop and optimize quantitative LC-MS bioanalytical assays for protein characterization and target engagement studies. The role supports drug discovery and development across multiple therapeutic programs through innovative mass spectrometry-based workflows and cross-functional collaboration.

What they're looking for

Doctorate in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with strong LC-MS training
Master's degree with 4+ years of relevant LC-MS bioanalysis experience, or Bachelor's with 6+ years
Hands-on expertise in LC-MS method development for complex biological matrices
Experience with proteomics workflows including peptide mapping and protein-drug adduct identification
Proficiency with automated sample preparation platforms and LC-MS instruments (triple quadrupole, Q-TOF, Orbitrap)
Strong troubleshooting and independent problem-solving abilities for analytical methods
Excellent communication and data interpretation skills for multidisciplinary teams

What you'll be doing

Develop, optimize, and execute quantitative LC-MS assays measuring target proteins, abundance, engagement, and turnover
Design and implement innovative bioanalytical strategies supporting drug-target interaction mechanistic understanding
Apply mass spectrometry workflows to assess samples from plasma, tissue, and in vitro systems
Troubleshoot assay development, sample preparation, data quality, and instrument performance independently
Collaborate with cross-functional teams to interpret bioanalytical data and communicate results clearly

Compensation$143,820.85–$194,581.15 USD

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