Senior Scientist - Computational Protein Design
Amgen · South San Francisco, CA
ResearchFull-timeCompany career page
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Role summary
Senior Scientist role focused on developing and deploying automated computational pipelines for large-scale protein binder design. The position supports molecular discovery efforts by accelerating generation of design candidates and libraries across multiple therapeutic targets using machine learning and structural biology approaches.
What they're looking for
- PhD in computational biology, structural biology, bioengineering, biophysics, or computer science with protein design focus
- OR Master's degree with 3+ years of protein design experience
- OR Bachelor's degree with 5+ years of protein design experience
- Demonstrated experience designing binders, minibinders, or antibodies computationally
- Strong Python programming and workflow automation skills for large-scale experiments
- Familiarity with AI/ML protein design tools such as AlphaFold, ProteinMPNN, or RFdiffusion
- Experience integrating computational design with experimental validation and screening workflows
What you'll be doing
- Develop and automate machine learning protein design workflows for binder generation
- Build scalable pipelines for designing large libraries of de novo proteins across multiple targets
- Apply computational methods to support multiplexed screening and receptor discovery efforts
- Collaborate with experimental scientists and data teams to enable rapid validation and iteration
- Contribute shared tools, workflows, and best practices within protein design community
Privacy & handoff
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