Vertex Spring Co-Op 2027, Process Development

Vertex Pharmaceuticals · Boston, MA

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Role summary

Vertex Pharmaceuticals seeks a Process Development Co-Op student for a 6-month program focused on cryopreservation research for cell therapy drug products. The role involves establishing imaging workflows, designing preservation studies, and integrating experimental data with computational modeling to advance Type 1 Diabetes therapeutics.

What they're looking for

Currently pursuing graduate or undergraduate degree in cell biology, molecular biology, biochemistry, or related scientific discipline
Experience with mammalian cell culture and aseptic laboratory techniques
Foundational knowledge of cell cryopreservation with hands-on freezing and thawing experience
Experience with cell microscopy including sample preparation, staining, and image acquisition
Knowledge of or experience with computational modeling for diffusion kinetics or molecular dynamics
Strong analytical, problem-solving, and organizational skills with attention to detail

What you'll be doing

Establish and standardize cryo-microscopy workflow for real-time imaging of stem cell-derived islets during preservation cycles
Design and execute cryopreservation studies with different cryoprotective formulations and document morphological responses
Develop computational modeling framework correlating cryoprotective agent diffusion kinetics with process parameters
Integrate experimental and computational results to characterize preservation effectiveness and optimize formulations
Maintain detailed laboratory records and author technical summaries and protocols in electronic notebooks

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