Senior Scientist II, Computational Chemistry
Revolution Medicines · Redwood City, CA
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Role summary
Revolution Medicines seeks a Senior Scientist II in Computational Chemistry to lead drug discovery programs using computational, cheminformatics, and data science approaches. The role involves designing and optimizing novel therapeutics targeting RAS-addicted cancers through advanced modeling and strategic collaboration with multidisciplinary teams.
What they're looking for
- Ph.D. in computational chemistry or related field
- 5+ years computational chemistry experience in biotechnology or pharmaceutical industry
- Demonstrated track record of impactful drug discovery contributions
- Expert knowledge of docking, virtual screening, and protein-ligand analysis methods
- Experience integrating SAR, structural biology, biophysical, and ADME/PK data
- Proficiency with physics-based modeling and free energy calculation methods
- Experience implementing and evaluating AI/ML workflows for molecular design
What you'll be doing
- Lead computational chemistry strategy on multidisciplinary discovery teams and drive compound design from hit finding through optimization
- Design and implement virtual screening workflows using structure-based and ligand-based computational methods
- Develop compound prioritization strategies and risk-mitigation approaches for medicinal chemistry partners
- Collaborate with Advanced Analytics to create, validate, and advocate AI/ML models for molecular design
- Devise strategies to enhance hit-finding capabilities for novel protein and protein-protein interaction targets
Privacy & handoff
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