Principal Scientist, Clinical Pharmacology & Pharmacometrics

Immunome · Bothell, WA

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Role summary

Immunome seeks a Principal Scientist in Clinical Pharmacology and Pharmacometrics to lead quantitative pharmacology strategy across oncology drug candidates. The role involves applying PK/PD modeling and simulation to inform dose selection and development decisions for targeted cancer therapies.

What they're looking for

Extensive experience in oncology quantitative pharmacology and pharmacometrics
Demonstrated expertise in clinical pharmacology strategy and drug development
Proficiency in PK/PD, PBPK, and pharmacometric modeling and simulation
Background in targeted oncology or antibody-drug conjugate development
Experience informing dose selection and regulatory submissions

What you'll be doing

Develop clinical pharmacology and pharmacometrics strategy for preclinical and clinical assets
Apply PK/PD and PBPK modeling to characterize drug absorption, disposition, and effect dynamics
Conduct pharmacometric modeling and simulations to support dose optimization decisions
Provide quantitative analysis to inform go/no-go development decisions

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