Principal Product Manager

Natera · Remote

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Role summary

Natera seeks an experienced Principal Product Manager to lead product strategy and execution for oncology genomic profiling initiatives. This senior individual contributor role demands end-to-end ownership of complex software platforms, cross-functional influence across engineering and clinical teams, and deep user empathy to deliver reliable diagnostic solutions.

What they're looking for

Proven experience leading end-to-end product strategy for complex, multi-system software platforms
Strong cross-functional influence and stakeholder alignment skills across technical and non-technical teams
Deep understanding of clinical workflows, lab operations, or healthcare software ecosystems
Demonstrated ability to translate scientific and technical requirements into scalable software specifications
Proficiency with Agile methodologies and product management best practices
Track record of rapid decision-making in ambiguous, fast-paced environments with high agency

What you'll be doing

Develop and execute multi-year software product roadmaps balancing rapid prototyping with commercial stability
Own full product lifecycle from order ingestion through lab execution to patient reporting across system boundaries
Lead cross-functional alignment of R&D, Engineering, Operations, Quality, and Regulatory stakeholders on roadmap execution
Conduct user research through operational shadowing and customer engagement to validate real-world problem-solving
Translate complex clinical and technical requirements into robust, scalable software specifications and architectural decisions

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