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Principal Machine Learning Scientist

Adaptive Biotechnologies · Remote

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Role summary

Adaptive Biotechnologies seeks a Principal Machine Learning Scientist to lead development of deep learning models predicting T cell receptor and peptide-MHC interactions. The role leverages proprietary immune datasets to design and validate models that advance diagnostic and therapeutic applications across the organization.

What they're looking for

  • PhD in quantitative discipline (machine learning, computational biology, computer science, or related field)
  • 12+ years of professional experience in machine learning or computational research
  • Expertise designing and training deep learning architectures for complex prediction tasks
  • Experience with protein language models, structure prediction, or generative modeling
  • Strong ability to translate biological principles into modeling strategies
  • Track record of high-impact publications and intellectual property contributions

What you'll be doing

  • Design, implement, and train novel deep learning models for TCR-pMHC specificity prediction
  • Integrate protein language models and structural prediction advances into immune receptor modeling
  • Lead benchmarking and evaluation strategies to validate model performance in practical applications
  • Influence experimental data generation strategy to improve long-term model performance
  • Partner with computational biology, immunology, and engineering teams to ensure scalability and alignment with clinical goals

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Date posted2 days ago
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