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Principal Biostatistician

Vertex Pharmaceuticals · Boston, MA

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BiometricsFull-time$152k–$228kCompany career page

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Role summary

Principal Biostatistician position supporting clinical trials and real-world data investigations across drug development programs. The role involves designing statistical infrastructure, authoring analysis plans, and collaborating with cross-functional teams to deliver study results and regulatory submissions.

What they're looking for

  • Ph.D. or Master's degree in Statistics or Biostatistics
  • 3+ years experience (Ph.D.) or 6+ years experience (Master's) in biostatistics or drug development
  • Advanced proficiency with SAS and R statistical software
  • Demonstrated expertise in advanced statistical methods for drug development
  • Strong written and verbal communication skills
  • Critical thinking and logical problem-solving abilities
  • Ability to collaborate effectively across functional teams

What you'll be doing

  • Conduct advanced statistical analyses for clinical trials, observational studies, and real-world data investigations including design and execution
  • Author Statistical Analysis Plans, table/figure/listing shells, and cross-functional data review documents with minimal guidance
  • Represent Biostatistics on clinical trial teams, providing technical guidance and regulatory interactions
  • Develop statistical sections of protocols including sample size estimates and randomization plans
  • Contribute to clinical study reports, methodological publications, and statistical review discussions

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