Associate Principal Scientist, Downstream Bioprocess Modeling, Digital Insights

Merck · Rahway, NJ +3 more

RoleLantern checked active

CMCFull-time$142k–$224kCompany career page

RoleLantern re-checked this role's application link recently and it was active — the employer has not confirmed it directly.

Role summary

Merck seeks an Associate Principal Scientist to develop and apply mechanistic models for downstream biologics purification processes. The role focuses on chromatography and unit operations modeling to guide process decisions across the drug development pipeline, with emphasis on technical leadership and mentorship.

What they're looking for

Ph.D. in Chemical Engineering, Bioengineering, or related field with 3+ years industrial/pharmaceutical experience
Deep expertise in preparative chromatography, transport phenomena, and separation science fundamentals
Hands-on experience building and validating mechanistic models using CADET, GoSilico, or equivalent platforms
Proficiency in parameter estimation, isotherm fitting, and uncertainty quantification for chromatography
Demonstrated track record applying models to real process decisions in resin selection, gradient design, or scale-up
Scientific leadership and mentorship experience; ability to grow modeling capability in junior scientists
Ability to communicate model credibility, limitations, and actionable insights to cross-functional teams

What you'll be doing

Build, calibrate, and validate mechanistic chromatography models for capture, polishing, and viral clearance steps
Design and execute parameter estimation studies with DSP scientists to generate calibration datasets and identify model parameters
Apply calibrated models to guide resin selection, gradient strategy, cycle design, robustness assessments, and scale-up decisions
Extend mechanistic modeling to adjacent unit operations including viral inactivation, ultrafiltration/diafiltration, and depth filtration
Mentor junior scientists on the Process Modeling & Analytics team; establish standards for model development and validation across the portfolio

Privacy & handoff

This role links to Merck's own application system. RoleLantern records your interest and checks the link, but the application happens on the employer's site and status updates may not come back to us. Clicking apply does not mark you as applied automatically.

What RoleLantern checked

This role is listed from an approved source. RoleLantern checks that the application link is live and how recently the role appeared — the employer has not confirmed it directly on RoleLantern.

RoleLantern checked active

RoleLantern checkedPay range listed

Date posted5 days ago

Last source checkToday

Salary listedListed

Location clearClear

Something look off? Let us know and we may ask the employer to verify it.

See how you match this role

Upload your CV to see which of this role's requirements your background supports, where there may be gaps, and what needs clarification. Private by default — we never sell your CV.

See my match